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It is revealed that the skull possesses magical powers, and after they both express a wish and touch the skull, Charlie grows up into his father's body, and Marshall shrinks into his son's body. While Charlie is holding the skull, they get into an argument about how they wish they could be in each other's bodies. Tensions run high in the family since Charlie can't understand why his father can't be more involved in his life. When Marshall returns, he takes Charlie for a few days while his mother, Robyn (Jane Kaczmarek), and stepfather Cliff, are vacationing. He puts it with one of Marshall's purchases, so that he and his accomplice Lillian Brookmeyer (Swoosie Kurtz) can make a switch.
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At the same time, an art thief named Turk (David Proval) tries to purchase the skull but has to find a way to smuggle it out of the country. He, and his girlfriend Sam (Corinne Bohrer) are on a trip to Thailand to purchase exotic merchandise. He is divorced and has a son named Charlie (Fred Savage) whom he has little time for. Marshall Seymour (Judge Reinhold) is Vice President of a Chicago department store, in charge of buying. In Thailand, a pair of thieves steal an ancient skull from a Buddhist monastery.